This variant affects the activity of another enzyme called alcohol dehydrogenase 1B, which is involved in the first step of alcohol metabolism. One of the ways in which acetaldehyde contributes to alcohol tolerance is by promoting the production of enzymes involved in its own metabolism. Studies have shown that chronic alcohol exposure can increase the expression of ADH and ALDH enzymes, allowing the body to break down acetaldehyde more quickly. This increased enzyme activity can help to reduce the levels ...
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2023